Pedemy All toolsAnswer one question at a time. The result gives the plan and empiric antibiotic doses by weight. Tap any earlier answer to change it.
This tool helps clinicians assess newborns for early-onset sepsis in the first 72 hours of life, for babies born at 35 weeks or more and those born at 34 6/7 weeks or less. It gives the plan and empiric ampicillin and gentamicin doses by weight.
Any ill-appearing newborn needs a blood culture and antibiotics. For babies at 35 weeks or more, maternal intraamniotic infection also leads to treatment. The tool then asks whether GBS prophylaxis was indicated but inadequate; adequate means penicillin, ampicillin or cefazolin IV given 4 hours or more before delivery. If prophylaxis was inadequate, babies with rupture of membranes for 18 hours or more, or born under 37 weeks, should have a blood culture considered and be observed for at least 36 hours; others are observed for at least 36 hours. For preterm babies, cesarean delivery for maternal reasons without labor or membrane rupture is low risk and does not need routine cultures or antibiotics.
Doses include ampicillin 50 mg/kg and gentamicin 4 mg/kg for babies at 35 weeks or more, with separate intervals for preterm babies. Antibiotics are stopped at 36–48 hours if the culture is negative and the baby is well. The tool also mentions the Kaiser Permanente sepsis calculator. It follows the AAP 2018 early-onset sepsis reports, the AAP 2019 GBS report and AAP Red Book 2024–2027 doses.
Stop at 36–48 hours if the blood culture is negative and the baby is well. The tool advises against continuing antibiotics for culture-negative sepsis based only on CRP or CBC results.
Adequate intrapartum prophylaxis is penicillin, ampicillin or cefazolin given IV 4 hours or more before delivery. Prophylaxis that was indicated but not given, or given under 4 hours before birth, is considered inadequate.
For babies at 35 weeks or more in the first week: ampicillin 50 mg/kg IV every 8 hours and gentamicin 4 mg/kg IV every 24 hours. Under 35 weeks, ampicillin is given every 12 hours and gentamicin intervals depend on gestational age. For meningitis, ampicillin is 100 mg/kg every 8 hours.
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